Sarah, a struggling young woman living in Brooklyn, agrees to volunteer as an experimental subject for a pharmaceutical company called Dynamic Health Cure to be the bearer of LEXX and make money to solve her financial troubles and take care of her mother who has Alzheimer's. A nano chip is planted into her cerebral cortex and designed to take control of the body in order to contain diseases as soon as they occur. But when the implant with artificial intelligence turns sinister and orders her to commit crimes, Sarah is plunged into a murderous spiral with only one choice to live or die.
退休摇滚明星强尼·博兹(Bill Cable 饰)在性行为的过程中被人用白丝巾捆绑双手后用冰锥残忍刺死。其女友凯瑟琳·特拉梅尔(Sharon Stone 饰)是一名作家,去年出版的小说中就有双手被白丝巾捆绑的退休摇滚明星被女友用冰锥刺死的情节。虽然特拉梅尔通过了谎言测试,但曾枪杀两位游客却被判无罪的尼克·柯兰警探(Michael Douglas 饰)坚持认为特拉梅尔在说谎。因为他自己也曾接受过谎言测试,并且通过了……